Semisolid Dosage
Daniels, Rolf
Semisolid Dosage - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (182 p.)
Open Access
Even in ancient times, semi-solid preparations for cutaneous application, popularly known as ointments, played an important role in human society. An advanced scientific investigation of “ointments” as dosage forms was initiated in the 1950s. It was only from then on that the intensive physico-chemical characterization of ointments as well as the inclusion of dermatological aspects led to a comprehensive understanding of the various interactions between the vehicle, the active ingredient and the skin. From then on, many researchers were involved in optimizing semi-solid formulations with respect to continuously changing therapeutic and patient needs. Aspects that have been dealt with were the optimization of dermato-biopharmaceutical properties and many different issues related to patient compliance, such as skin tolerance, applicability, and cosmetic appeal. Moreover, processing technology has been improved and analytical techniques were developed and refined in order to enable the improved characterization of the formulation itself as well as its interaction with the skin. This Special Issue serves to highlight and capture the contemporary progress and current research on semi-solid formulations as dermal drug delivery systems. We invite articles on all aspects of semi-solid formulations, highlighting the research currently undertaken to improve and better understand these complex drug delivery systems with respect to their formulation, processing and characterization issues.
Creative Commons
English
books978-3-03936-949-2 9783039369485 9783039369492
10.3390/books978-3-03936-949-2 doi
Medicine
dermal drug delivery diffusion cell Franz diffusion Skin-PAMPA Strat-M® membrane nanocarrier nonivamide methyl cellulose skin penetration substantivity thermogel tacrolimus formulation nanogels drug delivery human excised skin Jurkat cells in situ hydrogel-forming powder nitric oxide-releasing formulation S-nitrosoglutathione (GSNO) antibacterial wound dressing wound healing dermal delivery porcine skin in vitro permeation methadone pain in vitro permeation niacinamide solvent PAMPA skin curcumin deformable liposomes liposome surface charge hydrogel chitosan wound therapy IVRT metronidazole topical cream semisolid dosage forms sameness FDA’s SUPAC-SS guidance acceptance criteria positive and negative controls discriminatory ability Amphotericin B Sepigel 305® Leishmania infantum cutaneous leishmaniasis topical treatment birch bark extract oleogels hydrogen bonding triterpene rheology gel strength eosinophilic esophagitis budesonide xanthan gum guar gum mucoadhesion esophagus permeability rheological characterization pediatric medicine compounded preparation non-ionic emulsifiers intercellular lipids confocal Raman spectroscopy (CRS) polyethylene glycol alkyl ethers polyethylene glycol sorbitan fatty acid esters n/a
Semisolid Dosage - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (182 p.)
Open Access
Even in ancient times, semi-solid preparations for cutaneous application, popularly known as ointments, played an important role in human society. An advanced scientific investigation of “ointments” as dosage forms was initiated in the 1950s. It was only from then on that the intensive physico-chemical characterization of ointments as well as the inclusion of dermatological aspects led to a comprehensive understanding of the various interactions between the vehicle, the active ingredient and the skin. From then on, many researchers were involved in optimizing semi-solid formulations with respect to continuously changing therapeutic and patient needs. Aspects that have been dealt with were the optimization of dermato-biopharmaceutical properties and many different issues related to patient compliance, such as skin tolerance, applicability, and cosmetic appeal. Moreover, processing technology has been improved and analytical techniques were developed and refined in order to enable the improved characterization of the formulation itself as well as its interaction with the skin. This Special Issue serves to highlight and capture the contemporary progress and current research on semi-solid formulations as dermal drug delivery systems. We invite articles on all aspects of semi-solid formulations, highlighting the research currently undertaken to improve and better understand these complex drug delivery systems with respect to their formulation, processing and characterization issues.
Creative Commons
English
books978-3-03936-949-2 9783039369485 9783039369492
10.3390/books978-3-03936-949-2 doi
Medicine
dermal drug delivery diffusion cell Franz diffusion Skin-PAMPA Strat-M® membrane nanocarrier nonivamide methyl cellulose skin penetration substantivity thermogel tacrolimus formulation nanogels drug delivery human excised skin Jurkat cells in situ hydrogel-forming powder nitric oxide-releasing formulation S-nitrosoglutathione (GSNO) antibacterial wound dressing wound healing dermal delivery porcine skin in vitro permeation methadone pain in vitro permeation niacinamide solvent PAMPA skin curcumin deformable liposomes liposome surface charge hydrogel chitosan wound therapy IVRT metronidazole topical cream semisolid dosage forms sameness FDA’s SUPAC-SS guidance acceptance criteria positive and negative controls discriminatory ability Amphotericin B Sepigel 305® Leishmania infantum cutaneous leishmaniasis topical treatment birch bark extract oleogels hydrogen bonding triterpene rheology gel strength eosinophilic esophagitis budesonide xanthan gum guar gum mucoadhesion esophagus permeability rheological characterization pediatric medicine compounded preparation non-ionic emulsifiers intercellular lipids confocal Raman spectroscopy (CRS) polyethylene glycol alkyl ethers polyethylene glycol sorbitan fatty acid esters n/a