TRP Channels in Health and Disease
Dietrich, Alexander
TRP Channels in Health and Disease - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (266 p.)
Open Access
Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.
Creative Commons
English
books978-3-03921-083-1 9783039210824 9783039210831
10.3390/books978-3-03921-083-1 doi
n/a transient receptor potential channels photochromic ligands elementary immunology Purkinje cell EPSC substance P chemicals organ toxicity lymphocytes HSP70 physiology bioavailable inflammatory bowel disease platelets pollutants yeast regulatory T cells kinase Saccharomyces cerevisiae manganese cerebellum TRP channel NHERF inflammation nanoHPLC-ESI MS/MS TRPM7 chemical probes TRPM8 dorsal column nuclei TRPV2 TRPV3 calcitonin gene-related peptide TRPV1 ion channels transient receptor potential 2D gel electrophoresis MALDI-TOF MS(/MS) TRPV4 overproduction sulfur mustard oxidative stress graft versus host disease menthol topical chemosensor AP18 calcium signalling mucosal epithelium cuneate nucleus production platform TRPC channels ulcerative colitis channel structure xerostomia neutrophils cardiovascular system TRPC5 TRPC6 TRPC3 TRPC4 calcium signaling protein purification adipose tissue transient receptor potential (TRP) channels sodium TH17 diacylglycerol hypersensitivity TRPY1 GABAB HEK293 thrombosis ion channel TRPC pathophysiology SMAD toxicology endothelium calcium proteomics TRPA1 salivary glands TRP channels lipid mediators sensors radiation TRPM4 channel human medulla oblongata mGluR1 small molecules TRPC3 pharmacology
TRP Channels in Health and Disease - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (266 p.)
Open Access
Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.
Creative Commons
English
books978-3-03921-083-1 9783039210824 9783039210831
10.3390/books978-3-03921-083-1 doi
n/a transient receptor potential channels photochromic ligands elementary immunology Purkinje cell EPSC substance P chemicals organ toxicity lymphocytes HSP70 physiology bioavailable inflammatory bowel disease platelets pollutants yeast regulatory T cells kinase Saccharomyces cerevisiae manganese cerebellum TRP channel NHERF inflammation nanoHPLC-ESI MS/MS TRPM7 chemical probes TRPM8 dorsal column nuclei TRPV2 TRPV3 calcitonin gene-related peptide TRPV1 ion channels transient receptor potential 2D gel electrophoresis MALDI-TOF MS(/MS) TRPV4 overproduction sulfur mustard oxidative stress graft versus host disease menthol topical chemosensor AP18 calcium signalling mucosal epithelium cuneate nucleus production platform TRPC channels ulcerative colitis channel structure xerostomia neutrophils cardiovascular system TRPC5 TRPC6 TRPC3 TRPC4 calcium signaling protein purification adipose tissue transient receptor potential (TRP) channels sodium TH17 diacylglycerol hypersensitivity TRPY1 GABAB HEK293 thrombosis ion channel TRPC pathophysiology SMAD toxicology endothelium calcium proteomics TRPA1 salivary glands TRP channels lipid mediators sensors radiation TRPM4 channel human medulla oblongata mGluR1 small molecules TRPC3 pharmacology