Role of TCTP in Cell Biological and Disease Processes
Bommer, Ulrich-Axel
Role of TCTP in Cell Biological and Disease Processes - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (150 p.)
Open Access
Translationally controlled tumor protein (TCTP), also referred to as HRF or fortilin, is a multifunctional protein, expressed in all eukaryotic organisms from protozoa to humans. TCTP is involved in many basic biological processes, such as cell division, growth, and development. It is therefore not surprising that dysregulation of TCTP occurs in various disease processes, such as cardiovascular, allergic, and immune disorders. TCTP’s role in cancer-promoting pathways is well- documented, and the protein is considered a potential target for the design of new anti-cancer strategies. Therefore, an understanding of the core biological functions of TCTP, the mechanisms underlying its cellular regulation, and its involvement in disease processes is important. This book provides a current overview on the basic biological functions of TCTP and on its role in promoting a range of disease processes.
Creative Commons
English
books978-3-0365-2286-9 9783036522852 9783036522869
10.3390/books978-3-0365-2286-9 doi
Research & information: general
Biology, life sciences
Loxosceles brown spider TCTP venom toxin HRF allergy mast cells basophils IgE FcεRI translationally controlled tumor protein (TCTP) apoptosis conditional knockout mice development Nestin-cre neurogenesis neuronal progenitor cells perinatal death proliferation Mmi1 translationally controlled tumor protein autophagy reactive oxygen species rapamycin nitrogen starvation cancer phospho-TCTP DHA T-DM1 HER2-positive breast cancer TCTP (HRF fortilin) growth and development biological stress reactions regulation of protein synthesis regulated protein degradation cardiovascular diseases n/a
Role of TCTP in Cell Biological and Disease Processes - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (150 p.)
Open Access
Translationally controlled tumor protein (TCTP), also referred to as HRF or fortilin, is a multifunctional protein, expressed in all eukaryotic organisms from protozoa to humans. TCTP is involved in many basic biological processes, such as cell division, growth, and development. It is therefore not surprising that dysregulation of TCTP occurs in various disease processes, such as cardiovascular, allergic, and immune disorders. TCTP’s role in cancer-promoting pathways is well- documented, and the protein is considered a potential target for the design of new anti-cancer strategies. Therefore, an understanding of the core biological functions of TCTP, the mechanisms underlying its cellular regulation, and its involvement in disease processes is important. This book provides a current overview on the basic biological functions of TCTP and on its role in promoting a range of disease processes.
Creative Commons
English
books978-3-0365-2286-9 9783036522852 9783036522869
10.3390/books978-3-0365-2286-9 doi
Research & information: general
Biology, life sciences
Loxosceles brown spider TCTP venom toxin HRF allergy mast cells basophils IgE FcεRI translationally controlled tumor protein (TCTP) apoptosis conditional knockout mice development Nestin-cre neurogenesis neuronal progenitor cells perinatal death proliferation Mmi1 translationally controlled tumor protein autophagy reactive oxygen species rapamycin nitrogen starvation cancer phospho-TCTP DHA T-DM1 HER2-positive breast cancer TCTP (HRF fortilin) growth and development biological stress reactions regulation of protein synthesis regulated protein degradation cardiovascular diseases n/a