Biomedical Insights that Inform the Diagnosis of ME/CFS
Lidbury, Brett
Biomedical Insights that Inform the Diagnosis of ME/CFS - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (202 p.)
Open Access
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
Creative Commons
English
books978-3-03928-391-0 9783039283910 9783039283903
10.3390/books978-3-03928-391-0 doi
fatigue syndrome n/a work rehabilitation tryptophan metabolism substrate inhibition myalgic encephalomyelitis 3-dioxygenase ME (Myalgic Encephalomyelitis) assessment myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) muscles hypoacetylation circadian rhythm immune system chronic CFS (Chronic Fatigue Syndrome) energy metabolism ME/CFS immunological cytokine bistability diagnosis biomarker symptoms kynurenine pathway inflammation and immunity metabolism neuro-inflammation pathology signaling exercise Epstein Barr virus methylhistidine hypothalamic–pituitary–adrenal axis potential biomarkers critical point inflammation histone deacetylation participatory research neurology neuroimmune activin mitochondria patient-driven questionnaire medical retirement machine learning prognosis gut microbiota post-exertional malaise chronic fatigue syndrome mathematical model reference intervals diagnostic biomarker indoleamine-2
Biomedical Insights that Inform the Diagnosis of ME/CFS - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (202 p.)
Open Access
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
Creative Commons
English
books978-3-03928-391-0 9783039283910 9783039283903
10.3390/books978-3-03928-391-0 doi
fatigue syndrome n/a work rehabilitation tryptophan metabolism substrate inhibition myalgic encephalomyelitis 3-dioxygenase ME (Myalgic Encephalomyelitis) assessment myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) muscles hypoacetylation circadian rhythm immune system chronic CFS (Chronic Fatigue Syndrome) energy metabolism ME/CFS immunological cytokine bistability diagnosis biomarker symptoms kynurenine pathway inflammation and immunity metabolism neuro-inflammation pathology signaling exercise Epstein Barr virus methylhistidine hypothalamic–pituitary–adrenal axis potential biomarkers critical point inflammation histone deacetylation participatory research neurology neuroimmune activin mitochondria patient-driven questionnaire medical retirement machine learning prognosis gut microbiota post-exertional malaise chronic fatigue syndrome mathematical model reference intervals diagnostic biomarker indoleamine-2