Mechanisms of Innate Neuroprotection
Giuseppe Pignataro
Mechanisms of Innate Neuroprotection - Frontiers Media SA 2016 - 1 electronic resource (138 p.)
Open Access
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
Creative Commons
English
978-2-88919-929-7 9782889199297
10.3389/978-2-88919-929-7 doi
Neuroprotection postconditioning NCX Stroke seizure miRNA Alzheimer preconditioning
Mechanisms of Innate Neuroprotection - Frontiers Media SA 2016 - 1 electronic resource (138 p.)
Open Access
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
Creative Commons
English
978-2-88919-929-7 9782889199297
10.3389/978-2-88919-929-7 doi
Neuroprotection postconditioning NCX Stroke seizure miRNA Alzheimer preconditioning