Xenotransplantation : Comprehensive Study
Miyagawa, Shuji
Xenotransplantation : Comprehensive Study - IntechOpen 2020 - 1 electronic resource (156 p.)
Open Access
Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.
Creative Commons
English
intechopen.77924 9781789856644 9781789856637 9781789845211
10.5772/intechopen.77924 doi
Biomedical engineering
Biomedical engineering
Xenotransplantation : Comprehensive Study - IntechOpen 2020 - 1 electronic resource (156 p.)
Open Access
Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.
Creative Commons
English
intechopen.77924 9781789856644 9781789856637 9781789845211
10.5772/intechopen.77924 doi
Biomedical engineering
Biomedical engineering