Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

Changjun Yin

Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity - Frontiers Media SA 2017 - 1 electronic resource (235 p.)

Open Access

The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.


Creative Commons


English

978-2-88945-180-7 9782889451807

10.3389/978-2-88945-180-7 doi

Autoimmunity nonresolving peripheral tissue inflammation Autoinflammation Tertiary lymphoid organs dichotomies of immune responses disease immunity Immune Tolerance antigen