Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches
Bermejo, Marival
Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (206 p.)
Open Access
This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.
Creative Commons
English
books978-3-03928-493-1 9783039284931 9783039284924
10.3390/books978-3-03928-493-1 doi
in vitro dissolution microscopy imaging modulation ionotropic gelation laponite biowaiver beads model polymer/clay composite flow bioequivalence oral absorption curcumin P-gp liquid–liquid phase separation absorption large bowel dissolution Ussing chamber swelling fimasartan volume dexketoprofen gastrointestinal simulator transit controlled release formulations experimental and computational permeability methods magnetic resonance imaging GastroPlus™ in vitro–in vivo correlation (IVIVC) diltiazem MRI gut in vitro systems CYP3A4 poorly water-soluble drugs regional absorption intestinal permeability butyric acid intestinal drug absorption gastrointestinal absorption Biopharmaceutics Classification System (BCS) anti-inflammatory in vivo colon microbiota lipid-based formulations in situ single-pass perfusion metabolites biorelevant media fluconazole colon delivery modeling study mathematical modeling motility gellan gum gastrointestinal drug release large intestine lipolysis regional drug absorption
Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches - MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (206 p.)
Open Access
This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.
Creative Commons
English
books978-3-03928-493-1 9783039284931 9783039284924
10.3390/books978-3-03928-493-1 doi
in vitro dissolution microscopy imaging modulation ionotropic gelation laponite biowaiver beads model polymer/clay composite flow bioequivalence oral absorption curcumin P-gp liquid–liquid phase separation absorption large bowel dissolution Ussing chamber swelling fimasartan volume dexketoprofen gastrointestinal simulator transit controlled release formulations experimental and computational permeability methods magnetic resonance imaging GastroPlus™ in vitro–in vivo correlation (IVIVC) diltiazem MRI gut in vitro systems CYP3A4 poorly water-soluble drugs regional absorption intestinal permeability butyric acid intestinal drug absorption gastrointestinal absorption Biopharmaceutics Classification System (BCS) anti-inflammatory in vivo colon microbiota lipid-based formulations in situ single-pass perfusion metabolites biorelevant media fluconazole colon delivery modeling study mathematical modeling motility gellan gum gastrointestinal drug release large intestine lipolysis regional drug absorption