Microbial Virulence Factors
Leitão, Jorge H.
Microbial Virulence Factors - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (400 p.)
Open Access
Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.
Creative Commons
English
books978-3-03936-947-8 9783039369461 9783039369478
10.3390/books978-3-03936-947-8 doi
Research & information: general
Biology, life sciences
Aeromonas hydrophila LysR-family ΔlahS global regulator virulence Sclerotinia sclerotiorum SsNsd1 compound appressorium two-dimensional electrophoresis proteomics analysis differential expression proteins cystic fibrosis Pseudomonas aeruginosa Burkholderia cepacia complex small noncoding regulatory RNAs pathogenicity usg truA Salmonella enterica serovar Typhimurium oxidative stress intracellular survival pathogenomics coagulase-negative staphylococci virulence factors whole genome sequencing autotransporter covalent labeling bacterial surface protein SpyCatcher topology mapping virulence factor Candida host-pathogen interaction biofilm formation morphology immune evasion Trueperella pyogenes pyolysin infection immune response Actinomycetales Bordetella pertussis Hfq omics analysis T3SS serum resistance solute-binding proteins phytoplasma effector protein apple apple proliferation bacteria blood–brain barrier blood–cerebrospinal fluid barrier meningitis outer membrane vesicles (OMVs) Candida albicans antimicrobial peptides complement interspecies interactions inter-kingdom protection fungicidal activity fluconazole hyphae antimicrobial peptide EDTA primary ciliary dyskinesia anti-virulence sputum chronic infection Enterobacterales Klebsiella Enterobacter Citrobacter antibiotic resistance biofilm SPATEs UTIs cytotoxicity serine proteases 5637 bladder cells mucin gelatin actin protease Lon Dickeya solani plant pathogen motility type III secretion system resistance to stress lon expression pectinolytic enzymes gene expression manipulation inflammation persistence replicative niche actin proteolysis metalloproteinases protease ECP 32 grimelysin protealysin bacterial invasion microbial virulence factors bacterial pathogens fungal pathogens
Microbial Virulence Factors - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (400 p.)
Open Access
Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.
Creative Commons
English
books978-3-03936-947-8 9783039369461 9783039369478
10.3390/books978-3-03936-947-8 doi
Research & information: general
Biology, life sciences
Aeromonas hydrophila LysR-family ΔlahS global regulator virulence Sclerotinia sclerotiorum SsNsd1 compound appressorium two-dimensional electrophoresis proteomics analysis differential expression proteins cystic fibrosis Pseudomonas aeruginosa Burkholderia cepacia complex small noncoding regulatory RNAs pathogenicity usg truA Salmonella enterica serovar Typhimurium oxidative stress intracellular survival pathogenomics coagulase-negative staphylococci virulence factors whole genome sequencing autotransporter covalent labeling bacterial surface protein SpyCatcher topology mapping virulence factor Candida host-pathogen interaction biofilm formation morphology immune evasion Trueperella pyogenes pyolysin infection immune response Actinomycetales Bordetella pertussis Hfq omics analysis T3SS serum resistance solute-binding proteins phytoplasma effector protein apple apple proliferation bacteria blood–brain barrier blood–cerebrospinal fluid barrier meningitis outer membrane vesicles (OMVs) Candida albicans antimicrobial peptides complement interspecies interactions inter-kingdom protection fungicidal activity fluconazole hyphae antimicrobial peptide EDTA primary ciliary dyskinesia anti-virulence sputum chronic infection Enterobacterales Klebsiella Enterobacter Citrobacter antibiotic resistance biofilm SPATEs UTIs cytotoxicity serine proteases 5637 bladder cells mucin gelatin actin protease Lon Dickeya solani plant pathogen motility type III secretion system resistance to stress lon expression pectinolytic enzymes gene expression manipulation inflammation persistence replicative niche actin proteolysis metalloproteinases protease ECP 32 grimelysin protealysin bacterial invasion microbial virulence factors bacterial pathogens fungal pathogens