The Advances and Applications of Optogenetics
Govorunova, Elena G.
The Advances and Applications of Optogenetics - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (164 p.)
Open Access
This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.
Creative Commons
English
books978-3-03943-674-3 9783039436736 9783039436743
10.3390/books978-3-03943-674-3 doi
Research & information: general
Biology, life sciences
optogenetic tools neuroscience calcium sensor voltage sensor neurotransmitters optogenetics channelrhodopsins sodium calcium DC gate Optogenetics p53 AsLOV2 LINuS LEXY MIP PMI Chlamydomonas reinhardtii ion channel electrophysiology molecular dynamics simulations membrane-protein interaction energy of membrane deformation CTMD method, residual hydrophobic mismatch microbial rhodopsin channelrhodopsin membrane current hippocampal neurons light stimulation channelrhodopsin-2 photoreceptor BLUF modular domain resonance Raman flash photolysis hybrid QM/MM simulation two-photon azobenzene photoswitch photoswitching photocontrol all-optical electrophysiology microbial rhodopsins ion channels LOV domains membrane potential intracellular trafficking protein–protein interaction signaling
The Advances and Applications of Optogenetics - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 - 1 electronic resource (164 p.)
Open Access
This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.
Creative Commons
English
books978-3-03943-674-3 9783039436736 9783039436743
10.3390/books978-3-03943-674-3 doi
Research & information: general
Biology, life sciences
optogenetic tools neuroscience calcium sensor voltage sensor neurotransmitters optogenetics channelrhodopsins sodium calcium DC gate Optogenetics p53 AsLOV2 LINuS LEXY MIP PMI Chlamydomonas reinhardtii ion channel electrophysiology molecular dynamics simulations membrane-protein interaction energy of membrane deformation CTMD method, residual hydrophobic mismatch microbial rhodopsin channelrhodopsin membrane current hippocampal neurons light stimulation channelrhodopsin-2 photoreceptor BLUF modular domain resonance Raman flash photolysis hybrid QM/MM simulation two-photon azobenzene photoswitch photoswitching photocontrol all-optical electrophysiology microbial rhodopsins ion channels LOV domains membrane potential intracellular trafficking protein–protein interaction signaling