Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development (Record no. 38096)
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| fixed length control field | 02913naaaa2200289uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/70534 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | intechopen.85635 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.5772/intechopen.85635 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MMG |
| Source | bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bonifazi, Donato |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | InTechOpen |
| Date of publication, distribution, etc. | 2020 |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Drug discovery and development advances in the last decades allowed to find a treatment for many preventable diseases. However, all too often, children are excluded from these progresses since most of the new medicines have been discovered and developed for the adult population. Even if paediatricians routinely give drugs to children ‘off-label’, researchers have demonstrated that children do not respond to medications in the same way as adults. Furthermore, certain specific disorders are unique to children or occur in children differently than in adults. Besides specifically testing medicines in children in proper clinical studies taking into due account the peculiarity of this population, there is a growing recognition of the need to develop paediatric medicines having in mind the specificities of this vulnerable population. In this chapter, we will provide an overview on the drug discovery and development path for children highlighting challenges and new frontiers of each phase from the discovery to the preclinical and clinical development as well as we will provide a slightest hint about paediatric biomarkers discovery, age-appropriate formulation, pregnancy, and perinatal pharmacology and in silico pharmacology. Finally, pricing and reimbursement policies for medicines and new and existing research initiatives in the field will be discussed. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/3.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/3.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmacology |
| Source of heading or term | bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK) |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Migliaccio, Giovanni |
| Relationship | auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Intini, Angelica |
| Relationship | auth |
| 773 10 - HOST ITEM ENTRY | |
| Host Biblionumber | OAPEN Library ID: ONIX_20210602_10.5772/intechopen.85635_469 |
| Control subfield | nnaa |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf">https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf">https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/70534">https://directory.doabooks.org/handle/20.500.12854/70534</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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