Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients (Record no. 44201)

MARC details
000 -LEADER
fixed length control field 03729naaaa2200433uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/73718
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219211419.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88963-566-5
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889635665
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88963-566-5
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
072 #7 - SUBJECT CATEGORY CODE
Subject category code M
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCM
Source bicssc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Stefan Rommer, Paulus
Relationship edt
245 10 - TITLE STATEMENT
Title Multiple Sclerosis – From Bench to Bedside: Currents Insights into Pathophysiological Concepts and Their Potential Impact on Patients
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2020
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (253 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Research and advances in the treatment of Multiple Sclerosis (MS) is a story of growing success. Great progress has been made in identifying the molecular mechanisms that can be utilized to develop highly efficacious treatments for MS patients. Since the middle of the last century, when studies using an inflammatory autoimmune model of MS i.e. experimental autoimmune encephalitis (EAE) were initiated, research on MS has since led to an enormous growth of knowledge. The limitations arising from these animal models have been partially compensated by insights generated from histopathological, immunological, genetic, imaging and clinical studies of MS. The importance of T cells and, recently of B cells, in MS has been elucidated and the significance of CNS resident cells, particularly in the progressive course of MS has been highlighted. The importance of environmental factors and genetic predisposition have also been recognized and the interaction between th e individual and its environment seems to play key roles in the pathogenesis of this disease. However, definite causative agent(s) or single gene(s) involved in MS still remain unidentified. A deeper understanding of the immunological pathways involved goes hand in hand with further improving therapy for MS. Focal inflammation in MS, caused by de novo CNS infiltration, can be prevented effectively using peripherally-acting drugs. However, diffuse CNS intrinsic inflammation and neurodegeneration are not targeted by the current arsenal of therapeutics and patients with progressive disease courses remain difficult to treat. Generating insights into pathophysiological processes and the clinical translation of this knowledge have been a formula of success for treating inflammatory diseases. The future will show whether this will hold true for CNS-trapped inflammation and neurodegeneration and whether the ultimate goal – truly curing MS – will be possible.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Medicine
Source of heading or term bicssc
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Immunology
Source of heading or term bicssc
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Multiple Sclerosis
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Multiple Sclerois and Neuroimmunology
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Multiple sclerosis - drug therapy
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Multiple sclerosis - epidemiology
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Multiple sclerosis - etiology
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Weber, Martin S.
Relationship edt
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Illes, Zsolt
Relationship edt
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zettl, Uwe K.
Relationship edt
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Stefan Rommer, Paulus
Relationship oth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Weber, Martin S.
Relationship oth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Illes, Zsolt
Relationship oth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zettl, Uwe K.
Relationship oth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.frontiersin.org/research-topics/7689/multiple-sclerosis---from-bench-to-bedside-currents-insights-into-pathophysiological-concepts-and-th#overview">https://www.frontiersin.org/research-topics/7689/multiple-sclerosis---from-bench-to-bedside-currents-insights-into-pathophysiological-concepts-and-th#overview</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/73718">https://directory.doabooks.org/handle/20.500.12854/73718</a>
Access status 0
Public note DOAB: description of the publication

No items available.