Toxin-Antitoxin Systems in Pathogenic Bacteria (Record no. 44539)

MARC details
000 -LEADER
fixed length control field 04363naaaa2200865uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/76444
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219212106.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number books978-3-0365-0675-3
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783036506746
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783036506753
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3390/books978-3-0365-0675-3
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
072 #7 - SUBJECT CATEGORY CODE
Subject category code M
Source bicssc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Alonso, Juan Carlos
Relationship edt
245 10 - TITLE STATEMENT
Title Toxin-Antitoxin Systems in Pathogenic Bacteria
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Basel, Switzerland
Name of publisher, distributor, etc. MDPI - Multidisciplinary Digital Publishing Institute
Date of publication, distribution, etc. 2021
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (170 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Bacterial toxin–antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Medicine
Source of heading or term bicssc
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Uncontrolled term tuberculosis
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Uncontrolled term toxin-antitoxin systems
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Uncontrolled term bacterial cell death
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Uncontrolled term NAD+
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Uncontrolled term stress-response
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Uncontrolled term toxin–antitoxin system
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Uncontrolled term mazF
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Uncontrolled term type II
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Uncontrolled term toxin
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Uncontrolled term mRNA interferase
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Uncontrolled term X-ray crystallography
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Uncontrolled term cognate interactions
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Uncontrolled term cross-interactions
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Uncontrolled term molecular insulation
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Uncontrolled term antitoxin
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Uncontrolled term TA systems
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Uncontrolled term addiction
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Uncontrolled term anti-addiction
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Uncontrolled term type I toxin–antitoxin system
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Uncontrolled term small protein toxin structure
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Uncontrolled term Fst/Ldr family
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Uncontrolled term toxin–antitoxin
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Uncontrolled term M. tuberculosis
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Uncontrolled term bacteria
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Uncontrolled term pathogenesis
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Uncontrolled term protein–protein interactions
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Uncontrolled term cross-talk
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Uncontrolled term protein interface
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Uncontrolled term tolerance
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Uncontrolled term persistence
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Uncontrolled term cross-resistance
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Uncontrolled term toxin-antitoxin system
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Uncontrolled term PemI/PemK
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Uncontrolled term Klebsiella pneumoniae
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Uncontrolled term toxin–antitoxin systems
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Uncontrolled term toxin activation
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Uncontrolled term antibacterial agents
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Uncontrolled term bacterial persistence
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Uncontrolled term Stenotrophomonas maltophilia
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Uncontrolled term opportunistic pathogen
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Uncontrolled term clinical origin
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Uncontrolled term environmental origin
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Uncontrolled term biofilm
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Uncontrolled term antibiotic resistance
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Uncontrolled term cell wall inhibition
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Uncontrolled term nucleotide hydrolysis
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Uncontrolled term uridine diphosphate-N-acetylglucosamine
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Uncontrolled term n/a
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Alonso, Juan Carlos
Relationship oth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://mdpi.com/books/pdfview/book/3879">https://mdpi.com/books/pdfview/book/3879</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/76444">https://directory.doabooks.org/handle/20.500.12854/76444</a>
Access status 0
Public note DOAB: description of the publication

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