Carbohydrates: The yet to be tasted sweet spot of immunity (Record no. 45192)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03351naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/42688 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220219213357.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-625-8 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889196258 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-625-8 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Deirdre R. Coombe |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Carbohydrates: The yet to be tasted sweet spot of immunity |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (93 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Carbohydrates are extremely abundant bio-molecules; they are on all mammalian cell surfaces as well as on bacterial cell surfaces. In mammals most secreted proteins are glycosylated, with the glycan component comprising a significant amount by mass of the glycoprotein. Although, many years ago carbohydrate-protein recognition events were demonstrated as involved in invertebrate self-non self recognition, the contribution of carbohydrate-protein binding events to the mechanisms of the mammalian immune response was not embraced with the same enthusiasm. Adaptive immunity and the contribution of antibodies, T cells and T-lymphocyte sub-sets and protein antigen presentation dominated immunological theory. Unlike protein structures, carbohydrate structures are not template driven yet the numerous enzymes involved in carbohydrate biosynthesis and modification are encoded by a major component of the genome, and the expression of these enzymes is tightly regulated. As a consequence carbohydrate structures are also regulated, with different structures appearing according to the stage of cell differentiation and according to the age or health of the individual. The advent of technologies that have allowed carbohydrate structures and carbohydrate-protein binding events to be more easily interrogated has resulted in these types of interactions taking their place in modern immunology. We now know that glycans and their ligands (or lectins) are involved in numerous immunological pathways of both the innate and adaptive systems. However, it is clear that our understanding is still in its infancy, as more and more examples where carbohydrate structures contribute to aspects of the immune response are being recognised. The goal of this research topic is to explore the variety of roles undertaken by glycans and lectins in all aspects of the immune response. The particular focus is how the interactions of glycans with their ligands contribute to the mechanism of immune responses. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Heparan sulfate |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Siglec |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HIV |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | sialic acid |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | hyaluronan |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | galectin |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Heparanase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammation |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | glycosaminoglycan |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glycan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Christopher R. Parish |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/1481/carbohydrates-the-yet-to-be-tasted-sweet-spot-of-immunity">http://journal.frontiersin.org/researchtopic/1481/carbohydrates-the-yet-to-be-tasted-sweet-spot-of-immunity</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/42688">https://directory.doabooks.org/handle/20.500.12854/42688</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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