Roles of NF-κB in Cancer and Their Therapeutic Approaches (Record no. 45641)

MARC details
000 -LEADER
fixed length control field 03052naaaa2200409uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/58619
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219214233.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783038971177
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783038971184
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Véronique Baud (Ed.)
Relationship auth
245 10 - TITLE STATEMENT
Title Roles of NF-κB in Cancer and Their Therapeutic Approaches
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. MDPI - Multidisciplinary Digital Publishing Institute
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (X, 330 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Although mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity. NF-kB transcription factor family as emerged as such a promising target for cancer therapy. This Special Issue will explore the routes from NF-kB basic research, cancer research and oncogenomics into the development of NF-kB-based cancer therapeutics and biomarkers. We invite research and review papers in any area of the NF-kB field that are related, but not limited to, fundamental understanding of NF-kB signaling pathways, gene expression profiling, epigenetic regulation, diagnostic, prognostic and pharmacogenomic biomarkers, molecular targets driving the progression of human cancers, cancer drug development on these targets, clinical trial with new agents, and validation in animal models. We hope that this Special Issue reflects the exciting era that we are living in with respect to the field of NF-kB and its applications in cancer research.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by-nc-nd/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by-nc-nd/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term solid tumors hematological malignancies
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Uncontrolled term animal models
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Uncontrolled term biomarkers
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Uncontrolled term cancer targeted therapeutics
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Uncontrolled term oncogenomics
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Uncontrolled term mechanism-based drug development
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Uncontrolled term cancer targeted diagnosis
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Uncontrolled term molecular targets
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Uncontrolled term NF-kB subunit
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Uncontrolled term epigenetics
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Uncontrolled term NF-kB signaling pathways
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Uncontrolled term miRNA
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Uncontrolled term ubiquitin-proteasome pathway
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Uncontrolled term clinical trials
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Uncontrolled term gene expression profiling
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://www.mdpi.com/books/pdfview/book/711">http://www.mdpi.com/books/pdfview/book/711</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/58619">https://directory.doabooks.org/handle/20.500.12854/58619</a>
Access status 0
Public note DOAB: description of the publication

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