The CXCR4 Ligand/Receptor Family and the DPP4 Protease in High-Risk Cardiovascular Patients (Record no. 46660)

MARC details
000 -LEADER
fixed length control field 04213naaaa2200373uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/44468
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219220217.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88919-858-0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889198580
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88919-858-0
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Jurgen Bernhagen
Relationship auth
245 10 - TITLE STATEMENT
Title The CXCR4 Ligand/Receptor Family and the DPP4 Protease in High-Risk Cardiovascular Patients
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2016
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (163 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide, putting a major burden on life quality and social health care systems. Type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) have been identified as important risk factors for CVD, severely increasing the risk on e.g. myocardial infarction, and cardiovascular complications constitute the main cause of death in patients presenting with T2DM, CKD or a combination of both. As these pathologies are expected to rise alarmingly in the next decades, a better understanding of molecular and cellular mechanisms contributing to T2DM, CKD and CVD is required to improve prevention and treatment of these diseases. Furthermore, insight into the interplay between these pathologies and identification of molecular players interconnecting these comorbidities is of tremendous importance for optimal health management in the future. This Research Topic will focus on the chemokine receptor CXCR4 and its ligands CXCL12/SDF-1a and macrophage migration inhibitory factor (MIF) in the context of CVD and its link with T2DM and CKD, as well as address dipeptidyl peptidase-4 (DPP4) as an important protease destabilizing CXCL12. Chemokines and their receptors are important mediators of cell mobilization, recruitment and arrest, and also more broadly induce cell activation by triggering various intracellular signalling tracks. They control homeostatic conditions, but are also critically involved in inflammatory and pathological processes. Genome-wide association studies revealed single nucleotide polymorphisms connecting CXCL12 as well as MIF with CVD, and a role for both chemokines in T2DM and CKD has also been reported. In this review collection, current knowledge on molecular aspects of the CXCR4 ligand/receptor family and associated signalling pathways will be discussed. The physiological roles of CXCR4, CXCL12, MIF and DPP4 will be summarized, and recent findings on their function in pathological conditions of CVD, T2DM and CKD will be highlighted. This is combined with an extensive introduction providing insight into the pathologies of CVD, T2DM and CKD, discussing clinical features and common pathological aspects of these comorbidities on cellular and molecular level. Also, an overview of available animal models to study these diseases will be provided. This way, this Research Topic summarizes latest knowledge on this crucial molecular axis and its relationship with cardiovascular pathologies for both specialists and interested non-specialists and aims to stimulate further initiatives to unravel the mechanistic involvement of the CXCR4 ligand/receptor family in these morbidities, potentially paving the way for new therapeutical initiatives in the future.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term cardiovascular disease
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term chemokine
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term CXCL12/SDF-1
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term dipeptidyl peptidase
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term CXCR4
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term kidney disease
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term MIF
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term DPP4/CD26
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term diabetes
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term chemokine receptor
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Heidi Noels
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://journal.frontiersin.org/researchtopic/3372/the-cxcr4-ligandreceptor-family-and-the-dpp4-protease-in-high-risk-cardiovascular-patients">http://journal.frontiersin.org/researchtopic/3372/the-cxcr4-ligandreceptor-family-and-the-dpp4-protease-in-high-risk-cardiovascular-patients</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/44468">https://directory.doabooks.org/handle/20.500.12854/44468</a>
Access status 0
Public note DOAB: description of the publication

No items available.