Ca2+ Signaling and Heart Rhythm (Record no. 48127)

MARC details
000 -LEADER
fixed length control field 03057naaaa2200385uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/42564
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219223057.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88919-874-0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889198740
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88919-874-0
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Christopher L.-H. Huang
Relationship auth
245 10 - TITLE STATEMENT
Title Ca2+ Signaling and Heart Rhythm
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2016
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (133 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Heart
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Uncontrolled term Pak1
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Uncontrolled term SA node
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Uncontrolled term STIM1
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Uncontrolled term TRPC
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Uncontrolled term Ca2+
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Uncontrolled term Orai1
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Uncontrolled term PP2A
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Uncontrolled term voltage gated Ca2+ channels
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Yunbo Ke
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name R. John Solaro
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ming Lei
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://journal.frontiersin.org/researchtopic/2578/ca2-signaling-and-heart-rhythm">http://journal.frontiersin.org/researchtopic/2578/ca2-signaling-and-heart-rhythm</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/42564">https://directory.doabooks.org/handle/20.500.12854/42564</a>
Access status 0
Public note DOAB: description of the publication

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