BK Channels: Integrators of Cellular Signals in Health and Disease (Record no. 48471)

MARC details
000 -LEADER
fixed length control field 03235naaaa2200385uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/42315
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219223754.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88945-291-0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889452910
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88945-291-0
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Alex Dopico
Relationship auth
245 10 - TITLE STATEMENT
Title BK Channels: Integrators of Cellular Signals in Health and Disease
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (183 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term BK channel
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Uncontrolled term hydrogensulfide
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term maxi calcium activated potassium channel
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Uncontrolled term disease
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Uncontrolled term nervous system
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Uncontrolled term Slo
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Uncontrolled term KCNMA1
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term health
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term ethanol
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term ischemia
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Thomas M. Weiger
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Anton Hermann
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.frontiersin.org/research-topics/2413/bk-channels-integrators-of-cellular-signals-in-health-and-disease">https://www.frontiersin.org/research-topics/2413/bk-channels-integrators-of-cellular-signals-in-health-and-disease</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/42315">https://directory.doabooks.org/handle/20.500.12854/42315</a>
Access status 0
Public note DOAB: description of the publication

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