Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function (Record no. 48728)

MARC details
000 -LEADER
fixed length control field 04410naaaa2201033uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/45547
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219224322.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number books978-3-03921-689-5
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783039216895
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783039216888
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3390/books978-3-03921-689-5
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Pulido, Rafael
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245 10 - TITLE STATEMENT
Title Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. MDPI - Multidisciplinary Digital Publishing Institute
Date of publication, distribution, etc. 2019
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (240 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by-nc-nd/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Language note English
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700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lang, Roland
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856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://mdpi.com/books/pdfview/book/1856">https://mdpi.com/books/pdfview/book/1856</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/45547">https://directory.doabooks.org/handle/20.500.12854/45547</a>
Access status 0
Public note DOAB: description of the publication

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