The Neonatal Immune System: A Unique Host-Microbial Interface (Record no. 49186)

MARC details
000 -LEADER
fixed length control field 02774naaaa2200349uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/54426
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220219225240.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88945-403-7
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889454037
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88945-403-7
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Joseph M. Bliss
Relationship auth
245 10 - TITLE STATEMENT
Title The Neonatal Immune System: A Unique Host-Microbial Interface
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (175 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Emerging from the protective environment of the uterus, the newborn is exposed to a myriad of microbes, and quickly establishes a complex microbiome that shapes the infant’s biology in ways that are only now beginning to come to light. Among these exposures are a number of potential pathogens. The host responses to these pathogens in the neonatal period are unique, reflecting a developing immune system even with delivery at term. Preterm infants are delivered at a time when host defense mechanisms are even less developed and therefore face additional risk. As such, the organisms that cause disease in this period are different from the pathogens that are common in other age groups, or the disease they cause manifests in more severe fashion. Developmental alterations in both innate and adaptive immune responses in neonates have been documented among many cell types and pathways over the last several decades. Contemporary insights into the human immune system and methodologies that allow an “omics” approach to these questions have continued to provide new information regarding the mechanisms that underlie the human neonate as an “immunocompromised host.” This Research Topic highlights studies related to this unique host-pathogen interface. Contributions include those related to the innate or adaptive immune system of neonates, their response to microbial colonization or infection, and/or the pathogenesis of microbes causing disease in neonates.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Infection
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Neonate
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Candida
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Sepsis
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Necrotizing enterocolitis
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Vaccine
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Immunity
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Microbiome
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name James L. Wynn
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.frontiersin.org/research-topics/5017/the-neonatal-immune-system-a-unique-host-microbial-interface">https://www.frontiersin.org/research-topics/5017/the-neonatal-immune-system-a-unique-host-microbial-interface</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/54426">https://directory.doabooks.org/handle/20.500.12854/54426</a>
Access status 0
Public note DOAB: description of the publication

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