Glial Plasticity in Depression (Record no. 61695)

MARC details
000 -LEADER
fixed length control field 02803naaaa2200361uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/48665
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220031444.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88919-999-0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889199990
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88919-999-0
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Luisa Pinto
Relationship auth
245 10 - TITLE STATEMENT
Title Glial Plasticity in Depression
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2016
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (99 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Neuron
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term oligodendrocyte
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term antidepressant
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Depression
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term astrocyte
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Microglia
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Nuno Sousa
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Joao F. Oliveira
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Catarina A. Gomes
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sandra H. Vaz
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://journal.frontiersin.org/researchtopic/3264/glial-plasticity-in-depression">http://journal.frontiersin.org/researchtopic/3264/glial-plasticity-in-depression</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/48665">https://directory.doabooks.org/handle/20.500.12854/48665</a>
Access status 0
Public note DOAB: description of the publication

No items available.