Novel Approaches to the Analysis of Family Data in Genetic Epidemiology (Record no. 62846)
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| 000 -LEADER | |
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| fixed length control field | 03141naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/54864 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220033836.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-932-7 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889199327 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-932-7 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Robert C. Elston |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Novel Approaches to the Analysis of Family Data in Genetic Epidemiology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (84 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Regional heritability |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | prostate cancer |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | infectious diseases |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MCMC |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | combining studies screening |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | conditional-logistic linkage |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Informatics |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | autism |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nathan Morris |
| Relationship | auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jill S. Barnholtz-Sloan |
| Relationship | auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xiangqing Sun |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/886/novel-approaches-to-the-analysis-of-family-data-in-genetic-epidemiology">http://journal.frontiersin.org/researchtopic/886/novel-approaches-to-the-analysis-of-family-data-in-genetic-epidemiology</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/54864">https://directory.doabooks.org/handle/20.500.12854/54864</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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