The Role of Complement in Tumors (Record no. 62881)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03095naaaa2200493uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/73728 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220033913.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88963-576-4 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889635764 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88963-576-4 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | M |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCM |
| Source | bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rolfe, Barbara |
| Relationship | edt |
| 245 10 - TITLE STATEMENT | |
| Title | The Role of Complement in Tumors |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (107 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis. Despite its critical role in the regulation of immunity, the complement system has also been implicated in the pathogenesis of a range of inflammatory diseases, including cancer. The complement system can eliminate tumor cells via complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity. In turn, cancer cells are thought to evade complement-mediated destruction by up-regulating the expression of endogenous complement inhibitors. However research over the past 10 years has demonstrated that complement proteins, in particular the complement anaphylatoxins C3a and C5a, contribute to tumor growth and metastasis. Complement proteins have been shown to also promote tumor growth indirectly, either via host immune cells to promote an immunosuppressive microenvironment or via vascular cells to promote angiogenesis. However these proteins may also affect tumor cells directly by contributing to genetic instability and by promoting tumor growth and metastatic spread. This Research Topic gives an overview of the role of complement proteins in regulating tumor development, progression and metastasis. In addition, it provides perspectives on the potential targeting of complement in cancer therapy. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medicine |
| Source of heading or term | bicssc |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology |
| Source of heading or term | bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | complement |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cancer |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | metastasis |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | C5b-9 |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | C1q |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | C3a |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | C5a |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | complement regulatory proteins |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pio, Ruben |
| Relationship | edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Woodruff, Trent M. |
| Relationship | edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Markiewski, Maciej M. |
| Relationship | edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manthey, Helga D. |
| Relationship | edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rolfe, Barbara |
| Relationship | oth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pio, Ruben |
| Relationship | oth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Woodruff, Trent M. |
| Relationship | oth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Markiewski, Maciej M. |
| Relationship | oth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manthey, Helga D. |
| Relationship | oth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://www.frontiersin.org/research-topics/8435/the-role-of-complement-in-tumors#overview">https://www.frontiersin.org/research-topics/8435/the-role-of-complement-in-tumors#overview</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/73728">https://directory.doabooks.org/handle/20.500.12854/73728</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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