Glycolysis at 75: Is it time to tweak the first elucidated metabolic pathway in history? (Record no. 63751)
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| fixed length control field | 03915naaaa2200373uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/48725 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220035829.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-586-2 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889195862 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-586-2 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Avital Schurr |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Glycolysis at 75: Is it time to tweak the first elucidated metabolic pathway in history? |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (126 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Glycolysis, the pathway of enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate, was elucidated in 1940. For more than seven decades, it has been taught precisely the way its sequence was proposed by Embden, Meyerhof and Parnas. Accordingly, two outcomes of this pathway were proposed, an aerobic glycolysis, with pyruvate as its final product, and an anaerobic glycolysis, identical to the aerobic one, except for an additional reaction, where pyruvate is reduced to lactate. Several studies in the 1980s have shown that both muscle and brain tissues can oxidize and utilize lactate as an energy substrate, challenging this monocarboxylate’s reputation as a useless end-product of anaerobic glycolysis. These findings were met with great skepticism about the idea that lactate could be playing a role in bioenergetics. In the past quarter of a century monocarboxylate transporters (MCTs) were identified and localized in both cellular and mitochondrial membranes. A lactate receptor has been identified. Direct and indirect evidence now indicate that the enzyme lactate dehydrogenase (LDH) resides not only in the cytosol, as part of the glycolytic pathway machinery, but also in the mitochondrial outer membrane. The mitochondrial form of the enzyme oxidizes lactate to pyruvate and concomitantly produces the reducing agent NADH. These findings have shed light on a major drawback of the originally proposed aerobic version of the glycolytic pathway i.e., its inability to regenerate NAD+, as opposed to anaerobic glycolysis that features the cyclical ability of regenerating NAD+ upon pyruvate reduction to lactate by the cytosolic form of LDH. The malate-aspartate shuttle (MAS), a major redox shuttle in the brain, was proposed as an alternative pathway for NAD+ generation for aerobic glycolysis. Nonetheless, would MAS really be necessary for that function if glycolysis always proceeds to the end-products, lactate and NAD+? An additional dilemma the originally proposed aerobic glycolysis presents has to do with the glycolytic pathway of erythrocytes, which despite its highly aerobic environment, always produces lactate as its end-product. It is time to reexamine the original, dogmatic separation of glycolysis into two distinct pathways and put to test the hypothesis of a unified, singular pathway, the end-product of which is lactate, the real substrate of the mitochondrial TCA cycle. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Traumatic Brain Injury |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | monocarboxylate tansporters |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | signaling |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Energy Metabolism |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lactate |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Glycolysis |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | lactate receptor |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lactate dehydrogenase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pyruvate |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Evelyne Gozal |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/2499/glycolysis-at-75-is-it-time-to-tweak-the-first-elucidated-metabolic-pathway-in-history">http://journal.frontiersin.org/researchtopic/2499/glycolysis-at-75-is-it-time-to-tweak-the-first-elucidated-metabolic-pathway-in-history</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/48725">https://directory.doabooks.org/handle/20.500.12854/48725</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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