Autism Spectrum Disorders: From genotypes to phenotypes (Record no. 64194)
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| 000 -LEADER | |
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| fixed length control field | 03423naaaa2200397uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/41622 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220040813.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-680-7 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889196807 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-680-7 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Valsamma Eapen |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Autism Spectrum Disorders: From genotypes to phenotypes |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (93 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key _social brain_ regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neuroimaging |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | phenotypes |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | neurodevelopment |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Early Intervention |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | immune response |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genotypes |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Autism Spectrum Disorder |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Genetic Heterogeneity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | brain plasticity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | subtypes |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Charles Claudianos |
| Relationship | auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rudi Crncec |
| Relationship | auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Andrew J. Whitehouse |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/1093/autism-spectrum-disorders-from-genotypes-to-phenotypes">http://journal.frontiersin.org/researchtopic/1093/autism-spectrum-disorders-from-genotypes-to-phenotypes</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/41622">https://directory.doabooks.org/handle/20.500.12854/41622</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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