Fungal Pathogenesis in Humans: The Growing Threat (Record no. 64506)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03138naaaa2200445uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/48213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220041500.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | books978-3-03897-901-2 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783038979012 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783038979005 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3390/books978-3-03897-901-2 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Leal, Fernando |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Fungal Pathogenesis in Humans: The Growing Threat |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (232 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunistic fungal infections are probably the deadliest threat to these patients due to their difficult early diagnosis, the limited effect of antifungal drugs and the appearance of resistances. In recent years, a considerable effort has been devoted to investigating the role of many virulence traits in the pathogenic outcome of fungal infections. New virulence factors (hypoxia adaptation, CO2 sensing, pH regulation, micronutrient acquisition, secondary metabolites, immunity regulators, etc.) have been reported and their molecular mechanisms of action are being thoroughly investigated. The recent application of gene-editing technologies such as CRISPr-Cas9, has opened a whole new window to the discovery of new fungal virulence factors. Accurate fungal genotyping, Next Generation Sequencing and RNAseq approaches will undoubtedly provide new clues to interpret the plethora of molecular interactions controlling these complex systems. Unraveling their intimate regulatory details will provide insights for a more target-focused search or a rational design of more specific antifungal agents. This Special Issue is show significant discoveries, proofs of concept of new theories or relevant observations in fungal pathogenesis and its regulation. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CO2 sensing |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Micronutrient acquisition |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Biofilm formation |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Secondary metabolites and toxins |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Criptococcus |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fungal virulence |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immune evasion |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pH regulation |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pneumocysits |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aspergillus |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Regulation of antifungals resistance |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Candida |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fusarium |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Trehalose biosynthesis |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fungal genotyping |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Scedosporium |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://mdpi.com/books/pdfview/book/1326">https://mdpi.com/books/pdfview/book/1326</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/48213">https://directory.doabooks.org/handle/20.500.12854/48213</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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