Genetic Determinants of Human Longevity (Record no. 66089)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03910naaaa2200733uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/48392 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220044935.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | books978-3-03921-679-6 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039216796 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039216789 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3390/books978-3-03921-679-6 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rose, Giuseppina |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Genetic Determinants of Human Longevity |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (118 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | unknown zygosity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | exceptional longevity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TERC |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | xenobiotic-metabolizing enzymes |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | lifespan |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | gender-specific association |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | long-livers |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polymorphism |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cumulative incidence curves |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cardiovascular health |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | twins |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genetic determinants of human longevity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TERT |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SNP |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | moonlighting protein |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | longevity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genomics |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | APOE |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polygenic risk score |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | signal transduction |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | xenobiotics |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | survival |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IPMK |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genetic variation |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | genetic association study |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | molecular senescence |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | zygosity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | longevity-related genes |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | age-stratification |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | lipid profile |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | mortality |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | apolipoprotein E |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | aging |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | model systems |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | leukocyte telomere length |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | inositol phosphates |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | human lifespan |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | populations |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sørensen, Mette |
| Relationship | auth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dato, Serena |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://mdpi.com/books/pdfview/book/1752">https://mdpi.com/books/pdfview/book/1752</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/48392">https://directory.doabooks.org/handle/20.500.12854/48392</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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