The Biology and Treatment of Myeloid Leukaemias (Record no. 66614)

MARC details
000 -LEADER
fixed length control field 02696naaaa2200361uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/42238
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220050037.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783038427964
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783038427957
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Ewa Marcinkowska (Ed.)
Relationship auth
245 10 - TITLE STATEMENT
Title The Biology and Treatment of Myeloid Leukaemias
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. MDPI - Multidisciplinary Digital Publishing Institute
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (VI, 190 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. There has been an observed decrease in the global mortality from cancer, mostly atributable to improved, particularly early, detection and prevention. For many carcinomas and leukaemias in adults, once the disease has reached a certain stage there are no therapies that are able to erradicate the cancer cells and cure patients. There has been progress in the treatment of acute myeloid leukaemia (AML) and remissions are achievable; however, the presence of chemoresistent blast cells leads to most patients relapsing, and relapse is difficult to treat and thus patients die due to their disease. Targeting these resistent cells and the leukaemia stem cells, which sustain the leukaemia, is crucial for an effective therapy for AML. Moreover, an increasing number of diverse mutations have been described in AML cells that disrupt the ability of these cells to undergo differentiation. The use of pro-differentiating agents to drive the blast cells to mature, and subsequently undergo apoptosis, provides another approach to therapy. Differentiation therapy, using all-trans retinoic acid (ATRA), an inducer of granulocyte differentiation, has been highly successful in the case of acute promyeloicytic leukaemia, a sub-type of AML, turning this disease into a curable malignancy.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by-nc-nd/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by-nc-nd/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term mouse models
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Uncontrolled term myelopoiesis
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Uncontrolled term leukaemia stem cells
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Uncontrolled term gene aberrations
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Uncontrolled term new therapy strategies
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Uncontrolled term disease classification and diagnosis
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Uncontrolled term disease monitoring
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Uncontrolled term differentiation therapy
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Uncontrolled term cellular signaling and other molecular events
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Uncontrolled term acute myeloid leukaemias
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Geoffrey Brown (Ed.)
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://www.mdpi.com/books/pdfview/book/586">http://www.mdpi.com/books/pdfview/book/586</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/42238">https://directory.doabooks.org/handle/20.500.12854/42238</a>
Access status 0
Public note DOAB: description of the publication

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