Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics (Record no. 68234)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03564naaaa2200361uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/61392 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220053553.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88945-064-0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889450640 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88945-064-0 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Christian R. Gomez |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (113 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | microenvironment |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Stem Cells |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | hypoxia |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | stress |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HIF |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | tumor |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Leukemia |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | biomarkers |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | therapy |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pH |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/3972/tumor-hypoxia-impact-in-tumorigenesis-diagnosis-prognosis-and-therapeutics">http://journal.frontiersin.org/researchtopic/3972/tumor-hypoxia-impact-in-tumorigenesis-diagnosis-prognosis-and-therapeutics</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/61392">https://directory.doabooks.org/handle/20.500.12854/61392</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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