Polyamine Metabolism in Disease and Polyamine-Targeted Therapies (Record no. 68840)
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| 000 -LEADER | |
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| fixed length control field | 05844naaaa2201165uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/56626 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220054844.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | books978-3-03921-153-1 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039211531 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039211524 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3390/books978-3-03921-153-1 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Murray-Stewart, Tracy |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Polyamine Metabolism in Disease and Polyamine-Targeted Therapies |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (240 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | protein synthesis in cancer |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | neuroblastoma |
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| Uncontrolled term | epigenetics |
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| Uncontrolled term | Drosophila imaginal discs |
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| Uncontrolled term | pneumococcal pneumonia |
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| Uncontrolled term | transgenic mice |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | spermidine/spermine N1-acetyl transferase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ?-difluoromethylornithine |
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| Uncontrolled term | MYC |
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| Uncontrolled term | skeletal muscle |
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| Uncontrolled term | protein expression |
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| Uncontrolled term | curcumin |
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| Uncontrolled term | colorectal cancer |
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| Uncontrolled term | autophagy |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | human embryonic kidney 293 (HEK293) |
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| Uncontrolled term | melanoma |
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| Uncontrolled term | tumor immunity |
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| Uncontrolled term | Snyder-Robinson Syndrome |
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| Uncontrolled term | Streptococcus pneumoniae |
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| Uncontrolled term | B-lymphocytes |
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| Uncontrolled term | autoimmunity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | spermine oxidase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cell differentiation |
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| Uncontrolled term | diferuloylmethane |
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| Uncontrolled term | immunity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | antizyme |
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| Uncontrolled term | transgenic mouse |
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| Uncontrolled term | polyamine |
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| Uncontrolled term | hirsutism |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | chemoprevention |
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| Uncontrolled term | CRISPR |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | transglutaminase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polyamine analogs |
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| Uncontrolled term | NF-?B |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | spermine synthase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | atrophy |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | aging |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | oxidative stress |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | mast cells |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | African sleeping sickness |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | pancreatic ductal adenocarcinoma |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | eflornithine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | carcinogenesis |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ornithine decarboxylase |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polyamine transport inhibitor |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | putrescine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | neutrophils |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | spermidine |
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| Uncontrolled term | untranslated region |
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| Uncontrolled term | spermine |
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| Uncontrolled term | polyphenol |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | M2 macrophages |
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| Uncontrolled term | polyamine transport system |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | metabolism |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | difluoromethylorthinine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | DFMO |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | antizyme inhibitors |
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| Uncontrolled term | capsule |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polyamine transport |
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| Uncontrolled term | eosinophils |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MCF-7 cells |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | difluoromethylornithine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polyamine metabolism |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | mutant BRAF |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | polyamines |
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| Uncontrolled term | cadaverine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | proteomics |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | airway smooth muscle cells |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | breast cancer |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | X-linked intellectual disability |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | complementation |
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| Uncontrolled term | T-lymphocytes |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | bis(ethyl)polyamine analogs |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | antizyme 1 |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cancer |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | osteosarcoma |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://mdpi.com/books/pdfview/book/1582">https://mdpi.com/books/pdfview/book/1582</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/56626">https://directory.doabooks.org/handle/20.500.12854/56626</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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