Cellular Mechanisms of Ototoxicity (Record no. 69520)

MARC details
000 -LEADER
fixed length control field 03766naaaa2200373uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/42869
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220060352.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88945-483-9
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889454839
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88945-483-9
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Carlos Esquivel
Relationship auth
245 10 - TITLE STATEMENT
Title Cellular Mechanisms of Ototoxicity
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (292 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term blood-labyrinth barrier
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Uncontrolled term neurotoxicity
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term otoprotection
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Uncontrolled term aminoglycosides
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Uncontrolled term ototoxic synergy
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Uncontrolled term sensory disorders
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term cisplatin
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kelly Watts
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Peter S. Steyger
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Jian Zuo
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lisa Cunningham
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.frontiersin.org/research-topics/5317/cellular-mechanisms-of-ototoxicity">https://www.frontiersin.org/research-topics/5317/cellular-mechanisms-of-ototoxicity</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/42869">https://directory.doabooks.org/handle/20.500.12854/42869</a>
Access status 0
Public note DOAB: description of the publication

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