Metabolomics in Neurodegenerative Disease (Record no. 70696)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03978naaaa2200817uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/53236 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220063022.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | books978-3-03928-041-4 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039280414 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039280407 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3390/books978-3-03928-041-4 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Green, Brian |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Metabolomics in Neurodegenerative Disease |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (184 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The range of human neurodegenerative diseases continues to pose significant unmet medical needs for societies around the world. The progressive and terminal nature of these conditions places a considerable personal burden on the individual affected but also on public health systems and health services. Tens of millions of people are indiscriminately affected by various dementias, which are rising at an alarming rate. There are no cures for many conditions, and it is clear that treatments applied as early as possible could greatly improve outcomes for patients. Therefore, new disease classification and diagnostic tools should be a key priority. Metabolomics represents a relatively new field of analytical science, which can be extremely useful in the early diagnosis of disease. The relatively unique feature of metabolites is that they sit at the intersection between the genetic background of an organism and its environment. Because many neurodegenerative diseases are not genetically inherited (instead having a range of known genetic risk factors and also a large number of unknown environmental triggers) the field of metabolomics offers great promise for the discovery of new, biologically, and clinically relevant biomarkers for neurodegenerative disorders. It is already bringing forward new knowledge in terms of the mechanisms of neurodegenerative disease. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | glutamic acid |
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| Uncontrolled term | n/a |
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| Uncontrolled term | direct mass spectrometry |
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| Uncontrolled term | neurodegeneration |
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| Uncontrolled term | 6-OHDA |
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| Uncontrolled term | targeted mass spectrometry |
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| Uncontrolled term | mitochondrial dysfunction |
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| Uncontrolled term | myo-inositol |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | metabolomics |
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| Uncontrolled term | bile acids |
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| Uncontrolled term | subacute mild traumatic brain injury |
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| Uncontrolled term | age-related macular degeneration |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | metabolic pathways |
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| Uncontrolled term | energy metabolism |
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| Uncontrolled term | midbrain |
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| Uncontrolled term | Alzheimer’s disease |
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| Uncontrolled term | biomarkers |
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| Uncontrolled term | 1H NMR |
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| Uncontrolled term | Parkinson’s disease dementia |
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| Uncontrolled term | GC-MS |
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| Uncontrolled term | pathogenesis |
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| Uncontrolled term | tricarboxylic acid cycle |
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| Uncontrolled term | micro-dialysis |
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| Uncontrolled term | 13C-labeled succinate |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | metabolism |
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| Uncontrolled term | lipidomics |
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| Uncontrolled term | dementia with Lewy bodies |
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| Uncontrolled term | fatty acid |
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| Uncontrolled term | prodromal Parkinson’s disease |
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| Uncontrolled term | malonate |
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| Uncontrolled term | cerebral ischemia |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | mass spectrometry |
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| Uncontrolled term | retinal pigment epithelium |
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| Uncontrolled term | excitotoxicity |
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| Uncontrolled term | endothelin-1 |
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| Uncontrolled term | reperfusion |
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| Uncontrolled term | C. elegans |
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| Uncontrolled term | Streptomyces venezuelae |
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| Uncontrolled term | ?-synuclein aggregates |
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| Uncontrolled term | natural product |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | fatty acid metabolism |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | imaging mass spectrometry |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | LC-MS |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | drusen |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | cerebral palsy |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | plasma |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Parkinson’s disease |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://mdpi.com/books/pdfview/book/2226">https://mdpi.com/books/pdfview/book/2226</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/53236">https://directory.doabooks.org/handle/20.500.12854/53236</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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