The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration (Record no. 71323)

MARC details
000 -LEADER
fixed length control field 02835naaaa2200385uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/53229
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220064405.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88945-253-8
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889452538
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88945-253-8
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Enrique Cadenas
Relationship auth
245 10 - TITLE STATEMENT
Title The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2017
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (161 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Brain aging
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Mitochondria
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Energy Metabolism
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term neurodegeneration
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Neuroinflammation
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Perimenopause
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term redox homeostasis
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Alzheimer's disease
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term diabetes
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Jia Yao
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Fei Yin
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Roberta Diaz Brinton
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://journal.frontiersin.org/researchtopic/2807/the-metabolic-inflammatory-axis-in-brain-aging-and-neurodegeneration">http://journal.frontiersin.org/researchtopic/2807/the-metabolic-inflammatory-axis-in-brain-aging-and-neurodegeneration</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/53229">https://directory.doabooks.org/handle/20.500.12854/53229</a>
Access status 0
Public note DOAB: description of the publication

No items available.