Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer (Record no. 72002)

MARC details
000 -LEADER
fixed length control field 03117naaaa2200361uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/53628
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220065904.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88945-389-4
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889453894
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88945-389-4
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Jose Luis Garcia Perez
Relationship auth
245 10 - TITLE STATEMENT
Title Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (123 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS).To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term transposon
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Uncontrolled term genome stability
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term model organisms
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Uncontrolled term reverse transcriptase
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Uncontrolled term Mobile DNA
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Uncontrolled term RNA-dependent DNA polymerase
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Uncontrolled term cellular differentiation
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Uncontrolled term retrotransposon
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term DNA repair
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Tammy A. Morrish
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.frontiersin.org/research-topics/3215/mobile-genetic-elements-in-cellular-differentiation-genome-stability-and-cancer#articles">https://www.frontiersin.org/research-topics/3215/mobile-genetic-elements-in-cellular-differentiation-genome-stability-and-cancer#articles</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/53628">https://directory.doabooks.org/handle/20.500.12854/53628</a>
Access status 0
Public note DOAB: description of the publication

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