Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges (Record no. 74630)
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| fixed length control field | 05111naaaa2201285uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/51774 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220075830.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | books978-3-03921-707-6 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039217076 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783039217069 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3390/books978-3-03921-707-6 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gabazza, Esteban C. |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | MDPI - Multidisciplinary Digital Publishing Institute |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (348 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
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| Uncontrolled term | bleomycin |
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| Uncontrolled term | hepatic stellate cells |
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| Uncontrolled term | idiopathic pulmonary fibrosis |
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| Uncontrolled term | cancer-associated fibroblasts |
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| Uncontrolled term | fibrosis |
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| Uncontrolled term | non-small cell lung cancer (NSCLC) |
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| Uncontrolled term | smooth muscle tumor of uncertain malignant potential |
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| Uncontrolled term | interstitial fluid pressure |
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| Uncontrolled term | heterogeneity |
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| Uncontrolled term | hepatocytes |
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| Uncontrolled term | myometrium |
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| Uncontrolled term | tumor necrosis factor ? |
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| Uncontrolled term | tumor |
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| Uncontrolled term | tumor microenvironment |
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| Uncontrolled term | extracellular matrix |
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| Uncontrolled term | TAZ |
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| Uncontrolled term | carcinogenesis |
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| Uncontrolled term | cystic formation |
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| Uncontrolled term | pulmonary fibrosis |
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| Uncontrolled term | HBV |
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| Uncontrolled term | cytokine |
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| Uncontrolled term | genetic instability |
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| Uncontrolled term | diagnosis |
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| Uncontrolled term | EMT |
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| Uncontrolled term | crizotinib |
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| Uncontrolled term | Hippo pathway |
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| Uncontrolled term | GPR120 |
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| Uncontrolled term | marker |
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| Uncontrolled term | HCV |
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| Uncontrolled term | non-alcoholic steatohepatitis |
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| Uncontrolled term | pathology |
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| Uncontrolled term | common pathways |
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| Uncontrolled term | apoptosis |
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| Uncontrolled term | type I collagen |
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| Uncontrolled term | GPR40 |
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| Uncontrolled term | acute lung injury |
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| Uncontrolled term | uterine fibroid |
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| Uncontrolled term | pathophysiology |
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| Uncontrolled term | reactive oxygen species |
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| Uncontrolled term | butylidenephthalide |
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| Uncontrolled term | leiomyoma |
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| Uncontrolled term | cirrhosis |
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| Uncontrolled term | Erk1/2 |
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| Uncontrolled term | targeted therapy |
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| Uncontrolled term | TGF-? |
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| Uncontrolled term | mechanotransduction |
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| Uncontrolled term | therapy |
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| Uncontrolled term | breast cancer |
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| Uncontrolled term | hepatocellular carcinoma (HCC) |
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| Uncontrolled term | hepatic stellate cells (HSCs) |
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| Uncontrolled term | idiopathic pulmonary fibrosis (IPF) |
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| Uncontrolled term | cancer-associated fibroblasts (CAFs) |
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| Uncontrolled term | cancer |
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| Uncontrolled term | signal pathway |
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| Uncontrolled term | tumor stiffness |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://mdpi.com/books/pdfview/book/1794">https://mdpi.com/books/pdfview/book/1794</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/51774">https://directory.doabooks.org/handle/20.500.12854/51774</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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