Ribosome Inactivating Toxins (Record no. 74879)

MARC details
000 -LEADER
fixed length control field 02545naaaa2200313uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/58457
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220080418.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number books978-3-03897-249-5
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783038972495
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783038972488
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3390/books978-3-03897-249-5
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Daniel Gillet (Ed.)
Relationship auth
245 10 - TITLE STATEMENT
Title Ribosome Inactivating Toxins
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. MDPI - Multidisciplinary Digital Publishing Institute
Date of publication, distribution, etc. 2019
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (329 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses. This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by-nc-nd/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by-nc-nd/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term toxin
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Shiga toxin
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term ricin
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Ribosome inactivating protein
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Julien Barbier (Ed.)
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.mdpi.com/books/pdfview/book/1095">https://www.mdpi.com/books/pdfview/book/1095</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/58457">https://directory.doabooks.org/handle/20.500.12854/58457</a>
Access status 0
Public note DOAB: description of the publication

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