Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins (Record no. 76491)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02668naaaa2200325uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/49645 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220084009.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-961-7 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889199617 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-961-7 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Giovanni Blandino |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (97 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | mouse models |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | mutant p53 |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | dominant netagive |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | therapies |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oncogenic addiction |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | gain of function |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ygal Haupt |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/3592/human-tumor-derived-p53-mutants-a-growing-family-of-oncoproteins">http://journal.frontiersin.org/researchtopic/3592/human-tumor-derived-p53-mutants-a-growing-family-of-oncoproteins</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/49645">https://directory.doabooks.org/handle/20.500.12854/49645</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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