New Developments in the Pathogenesis of Rheumatoid Arthritis (Record no. 78801)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01949naaaa2200313uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/54567 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220093126.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 63175 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9789535129691 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9789535129707 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.5772/63175 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lazaros I. Sakkas |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | New Developments in the Pathogenesis of Rheumatoid Arthritis |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | IntechOpen |
| Date of publication, distribution, etc. | 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (164 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | All rights reserved |
| -- | http://oapen.org/content/about-rights |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Medicine |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immunology |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoimmunology |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Allergology and Rheumatology |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Health Sciences |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://www.intechopen.com/books/new-developments-in-the-pathogenesis-of-rheumatoid-arthritis">https://www.intechopen.com/books/new-developments-in-the-pathogenesis-of-rheumatoid-arthritis</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/54567">https://directory.doabooks.org/handle/20.500.12854/54567</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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