Development of Humanized Mouse Models for Infectious Diseases and Cancer (Record no. 78919)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03312naaaa2200409uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/73635 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220093356.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88963-481-1 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889634811 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88963-481-1 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | M |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCM |
| Source | bicssc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tsuji, Moriya |
| Relationship | edt |
| 245 10 - TITLE STATEMENT | |
| Title | Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (169 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist and generating new knowledge in the context of human target cells in an in vivo setting. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medicine |
| Source of heading or term | bicssc |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology |
| Source of heading or term | bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | humanized mice in infectious disease research |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | humanized mice in cancer research |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | new humanized mouse models |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | humanized mice for HIV |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | malaria |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | vaccines and therapeutics |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | improved humanized mouse models |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Akkina, Ramesh |
| Relationship | edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tsuji, Moriya |
| Relationship | oth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Akkina, Ramesh |
| Relationship | oth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://www.frontiersin.org/research-topics/5454/development-of-humanized-mouse-models-for-infectious-diseases-and-cancer#articles">https://www.frontiersin.org/research-topics/5454/development-of-humanized-mouse-models-for-infectious-diseases-and-cancer#articles</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/73635">https://directory.doabooks.org/handle/20.500.12854/73635</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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