Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (Record no. 80042)
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| fixed length control field | 03138naaaa2200349uu 4500 |
| 001 - CONTROL NUMBER | |
| control field | https://directory.doabooks.org/handle/20.500.12854/47206 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220220095923.0 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-472-8 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889194728 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-472-8 |
| Terms of availability | doi |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alberto Granato |
| Relationship | auth |
| 245 10 - TITLE STATEMENT | |
| Title | Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 electronic resource (104 p.) |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Source of term | star |
| Standardized terminology for access restriction | Unrestricted online access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| -- | https://creativecommons.org/licenses/by/4.0/ |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | glial cells |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | development |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Amygdala |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Fetal Alcohol Spectrum Disorders |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cerebral Cortex |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Intellectual Disability |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | epigenetics |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Andrea De Giorgio |
| Relationship | auth |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/2207/experimental-models-of-early-exposure-to-alcohol-a-way-to-unravel-the-neurobiology-of-mental-retarda">http://journal.frontiersin.org/researchtopic/2207/experimental-models-of-early-exposure-to-alcohol-a-way-to-unravel-the-neurobiology-of-mental-retarda</a> |
| Access status | 0 |
| Public note | DOAB: download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Host name | www.oapen.org |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/47206">https://directory.doabooks.org/handle/20.500.12854/47206</a> |
| Access status | 0 |
| Public note | DOAB: description of the publication |
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