The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration (Record no. 81338)

MARC details
000 -LEADER
fixed length control field 03231naaaa2200349uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/61874
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220102842.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88945-410-5
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889454105
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88945-410-5
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Francisco J. Rivera
Relationship auth
245 10 - TITLE STATEMENT
Title The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2018
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (174 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Tissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Angiogenesis
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Platelets and Platelets Lysate
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Blood Vessels and Endothelial Cells
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Granulocyte Colony Stimulating Factor (G-CSF)
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Uncontrolled term Pericytes
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Stem and Progenitor Cells
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Vascular Niche
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term Tissue Repair and Regeneration
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Ludwig Aigner
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://www.frontiersin.org/research-topics/3255/the-vascular-niche-in-tissue-repair-a-therapeutic-target-for-regeneration">https://www.frontiersin.org/research-topics/3255/the-vascular-niche-in-tissue-repair-a-therapeutic-target-for-regeneration</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/61874">https://directory.doabooks.org/handle/20.500.12854/61874</a>
Access status 0
Public note DOAB: description of the publication

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