Iron as Therapeutic Targets in Human Diseases Volume 1 (Record no. 82139)

MARC details
000 -LEADER
fixed length control field 09028naaaa2202689uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/50679
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220104547.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number books978-3-03928-083-4
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783039280827
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783039280834
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3390/books978-3-03928-083-4
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Gozzelino, Raffaella
Relationship auth
245 10 - TITLE STATEMENT
Title Iron as Therapeutic Targets in Human Diseases Volume 1
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. MDPI - Multidisciplinary Digital Publishing Institute
Date of publication, distribution, etc. 2020
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (472 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by-nc-nd/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Language note English
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700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Poli, Maura
Relationship auth
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Arosio, Paolo
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
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Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/50679">https://directory.doabooks.org/handle/20.500.12854/50679</a>
Access status 0
Public note DOAB: description of the publication

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