Chemokines and chemokine receptors in brain homeostasis (Record no. 82193)

MARC details
000 -LEADER
fixed length control field 03542naaaa2200361uu 4500
001 - CONTROL NUMBER
control field https://directory.doabooks.org/handle/20.500.12854/43103
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20220220104707.0
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 978-2-88919-616-6
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9782889196166
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.3389/978-2-88919-616-6
Terms of availability doi
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title English
042 ## - AUTHENTICATION CODE
Authentication code dc
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Richard M. Ransohoff
Relationship auth
245 10 - TITLE STATEMENT
Title Chemokines and chemokine receptors in brain homeostasis
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Frontiers Media SA
Date of publication, distribution, etc. 2015
300 ## - PHYSICAL DESCRIPTION
Extent 1 electronic resource (124 p.)
506 0# - RESTRICTIONS ON ACCESS NOTE
Terms governing access Open Access
Source of term star
Standardized terminology for access restriction Unrestricted online access
520 ## - SUMMARY, ETC.
Summary, etc. Virtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain enviroment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Creative Commons
Use and reproduction rights https://creativecommons.org/licenses/by/4.0/
Source of term cc
-- https://creativecommons.org/licenses/by/4.0/
546 ## - LANGUAGE NOTE
Language note English
653 ## - INDEX TERM--UNCONTROLLED
Uncontrolled term brain pathology
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Uncontrolled term Pain
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Uncontrolled term neurotransmission
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Uncontrolled term Glioblastoma
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Uncontrolled term neurons-glia cross-talk
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Uncontrolled term Inflammation
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Uncontrolled term Brain homeostasis
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Uncontrolled term Chemokines
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Uncontrolled term Chemokine receptors
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Flavia Trettel
Relationship auth
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="http://journal.frontiersin.org/researchtopic/2476/chemokines-and-chemokine-receptors-in-brain-homeostasis">http://journal.frontiersin.org/researchtopic/2476/chemokines-and-chemokine-receptors-in-brain-homeostasis</a>
Access status 0
Public note DOAB: download the publication
856 40 - ELECTRONIC LOCATION AND ACCESS
Host name www.oapen.org
Uniform Resource Identifier <a href="https://directory.doabooks.org/handle/20.500.12854/43103">https://directory.doabooks.org/handle/20.500.12854/43103</a>
Access status 0
Public note DOAB: description of the publication

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