Recent Progress in Solid Dispersion Technology
Material type:
ArticleLanguage: English Publication details: MDPI - Multidisciplinary Digital Publishing Institute 2019Description: 1 electronic resource (204 p.)ISBN: - books978-3-03921-502-7
 - 9783039215010
 - 9783039215027
 
- thermodynamic modeling
 - molecular dynamics simulation
 - poorly soluble drugs
 - amorphous solid dispersions
 - dissolution enhancement
 - crystallization tendency
 - continuous processing
 - stability
 - milling
 - granulation
 - thermal analysis
 - amorphous
 - ball milling
 - pharmaceutical glass
 - dissolution
 - rebamipide
 - poloxamer
 - classification
 - polyelectrolytes
 - amorphisation
 - self-assembly
 - dissolution rate
 - miscibility
 - bioavailability
 - solubility
 - evaporation
 - mesoporous
 - polyelectrolyte excipient matrix
 - polymer
 - bicaludamide
 - phase diagram
 - Weibull dissolution model
 - spectroscopic techniques
 - anticancer drugs
 - manufacturing methods
 - nucleation
 - molecular complex
 - nanoaggregates
 - enrofloxacin
 - accelerated stability test
 - solubility enhancement
 - amorphous solid dispersion
 - tadalafil
 - process development
 - amorphous polymeric salt
 - Wood’s apparatus
 - hot melt extrusion
 - solid dispersions
 - intrinsic dissolution rate
 - solid dispersion
 - interaction
 - crystallization
 - spray drying
 - characterization
 - ciprofloxacin
 
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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
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