TY  - GEN
AU  - Kleifeld,Oded
AU  - Levin-Kravets,Olga
AU  - Prag,Gali
AU  - Ben-Aroya,Shay
AU  - Attali,Ilan
AU  - Keren-Kaplan,Tal
TI  - Chapter Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10
SN  - intechopen.85283
PY  - 2019///
PB  - InTechOpen
KW  - Proteins
KW  - bicssc
KW  - ubiquitin receptor, crystal structure, ubiquitylated ubiquitin receptor, regulation mechanisms, cargo shuttle
N1  - Open Access
N2  - Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes into cellular response. They harbor a ubiquitin-binding domain and a response element. Interestingly, Ub-receptors are also regulated by ubiquitylation and deubiquitylation. However, until recently, the molecular details and the significance of this regulation remained enigmatic. Rpn10 is a Ub-receptor that shuttles ubiquitylated targets to the proteasome for degradation. Here we review recent data on Rpn10, with emphasis on its regulation by ubiquitylation
UR  - https://library.oapen.org/bitstream/20.500.12657/49334/1/67393.pdf
UR  - https://library.oapen.org/bitstream/20.500.12657/49334/1/67393.pdf
UR  - https://directory.doabooks.org/handle/20.500.12854/70352
ER  -