TY  - GEN
AU  - Nikitovic,Dragana
AU  - Perez,Serge
AU  - Nikitovic,Dragana
AU  - Perez,Serge
TI  - Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges
SN  - books978-3-0365-2676-8
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - Biology, life sciences
KW  - GAGs
KW  - Hyaluronic
KW  - Acid
KW  - Heparan
KW  - (Sulfate)
KW  - Heparin
KW  - Heparosan
KW  - Chondroitin
KW  - Dermatan
KW  - Keratan
KW  - like
KW  - Peri
KW  - and
KW  - Extracellular
KW  - Matrix
KW  - Regulation
KW  - &amp
KW  - Biosynthesis
KW  - of
KW  - GAG
KW  - Extraction
KW  - Synthesis
KW  - (chemical
KW  - metabolic
KW  - engineering,...)
KW  - Characterization
KW  - sequence
KW  - molecular
KW  - weight
KW  - degree
KW  - polymerization
KW  - 3D
KW  - structures,....)
KW  - structure/properties
KW  - relationships
KW  - oligosaccharides
KW  - Glycobiology
KW  - structure/function
KW  - relationship
KW  - Protein-GAG
KW  - complexes
KW  - in
KW  - disease
KW  - GAG-based
KW  - biomaterials
KW  - as
KW  - nanocarriers
N1  - Open Access
N2  - Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled “Exploring the multifaceted roles of glycosaminoglycans (GAGs)—new advances and further challenges”, features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide.A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting “omics” fields
UR  - https://mdpi.com/books/pdfview/book/4762
UR  - https://directory.doabooks.org/handle/20.500.12854/77144
ER  -