Serra, Raffaele <br/><br/>
Matrix Metalloproteinases in Health and Disease 

 - Basel, Switzerland  MDPI - Multidisciplinary Digital Publishing Institute  2020 
 - 1 electronic resource (196 p.) 
<br/><br/> Open Access 
<br/><br/> Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual’s disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03943-053-6 9783039430529 9783039430536 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03943-053-6  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Humanities<br/>Social interaction
<br/><br/><label>Subjects--Index Terms: </label>hypersensitivity pneumonitis metalloproteinases genetic association autoantibodies MMP1 MMP2 SNPs MMPs TIMPs CKD peripheral vascular disease biomarkers proteinuria eGFR PAD. NGAL statins arterial aneurysms patients collagenases Crohn’s disease dental caries mouth periodontitis matrix metalloproteinase-9 dialysis on-line hemodiafiltration high-flux dialysis renal replacement therapy kidney transplantation Mac-1 CD147 leukocytes platelets adhesion integrin αMβ2 matrix metalloproteinases TIMP synthetic inhibitors RECK matrix metalloproteinase MAPKs ischemia/reperfusion eNOS iNOS inflammatory bowel disease inflammation NO MMP-9 cGMP Caco-2 matrix metalloproteinase-7 fibrosis acute kidney injury chronic kidney disease apoptosis health disease