TY - GEN AU - Dietrich,Alexander TI - TRP Channels in Health and Disease SN - books978-3-03921-083-1 PY - 2019/// PB - MDPI - Multidisciplinary Digital Publishing Institute KW - n/a KW - transient receptor potential channels KW - photochromic ligands KW - elementary immunology KW - Purkinje cell KW - EPSC KW - substance P KW - chemicals KW - organ toxicity KW - lymphocytes KW - HSP70 KW - physiology KW - bioavailable KW - inflammatory bowel disease KW - platelets KW - pollutants KW - yeast KW - regulatory T cells KW - kinase KW - Saccharomyces cerevisiae KW - manganese KW - cerebellum KW - TRP channel KW - NHERF KW - inflammation KW - nanoHPLC-ESI MS/MS KW - TRPM7 KW - chemical probes KW - TRPM8 KW - dorsal column nuclei KW - TRPV2 KW - TRPV3 KW - calcitonin gene-related peptide KW - TRPV1 KW - ion channels KW - transient receptor potential KW - 2D gel electrophoresis KW - MALDI-TOF MS(/MS) KW - TRPV4 KW - overproduction KW - sulfur mustard KW - oxidative stress KW - graft versus host disease KW - menthol KW - topical KW - chemosensor KW - AP18 KW - calcium signalling KW - mucosal epithelium KW - cuneate nucleus KW - production platform KW - TRPC channels KW - ulcerative colitis KW - channel structure KW - xerostomia KW - neutrophils KW - cardiovascular system KW - TRPC5 KW - TRPC6 KW - TRPC3 KW - TRPC4 KW - calcium signaling KW - protein purification KW - adipose tissue KW - transient receptor potential (TRP) channels KW - sodium KW - TH17 KW - diacylglycerol KW - hypersensitivity KW - TRPY1 KW - GABAB KW - HEK293 KW - thrombosis KW - ion channel KW - TRPC KW - pathophysiology KW - SMAD KW - toxicology KW - endothelium KW - calcium KW - proteomics KW - TRPA1 KW - salivary glands KW - TRP channels KW - lipid mediators KW - sensors KW - radiation KW - TRPM4 channel KW - human medulla oblongata KW - mGluR1 KW - small molecules KW - TRPC3 pharmacology N1 - Open Access N2 - Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options UR - https://mdpi.com/books/pdfview/book/1388 UR - https://directory.doabooks.org/handle/20.500.12854/61371 ER -