Subramanian, Subree <br/><br/>
microRNA Regulation in Health and Disease 

 -  MDPI - Multidisciplinary Digital Publishing Institute  2020 
 - 1 electronic resource (154 p.) 
<br/><br/> Open Access 
<br/><br/> MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03921-715-1 9783039217151 9783039217144 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03921-715-1  doi 
<br/><br/><label>Subjects--Index Terms: </label>microRNAs n/a lipoprotein myofibroblast miR-148a C2C12 cell line endometrial receptivity interstitial lung disease exon switch atherosclerosis colorectal cancer let-7 miR-125b idiopathic pulmonary fibrosis biomarker recurrent implantation failure severe acute respiratory syndrome coronavirus miRSNP transfer miR-106a-5p somatostatin analogues neuroendocrine tumors gene expression uremia HKII miRNAs metabolic interactions non-Hodgkin lymphoma PIK3R1 small RNA miR-7 Hexokinase 2 CD34 cryptic splicing systemic sclerosis small RNA-seq myogenic differentiation proteomics CD34 cell-clusters palindromic small RNA infertility gut microbiota ORF miRNA target DNA complemented palindrome rs17723799 complemented palindromic small RNA MIR143 microRNA cancer muscle atrophy