TY  - GEN
AU  - Subramanian,Subree
AU  - Steer,Clifford
TI  - microRNA Regulation in Health and Disease
SN  - books978-3-03921-715-1
PY  - 2020///
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - microRNAs
KW  - n/a
KW  - lipoprotein
KW  - myofibroblast
KW  - miR-148a
KW  - C2C12 cell line
KW  - endometrial receptivity
KW  - interstitial lung disease
KW  - exon switch
KW  - atherosclerosis
KW  - colorectal cancer
KW  - let-7
KW  - miR-125b
KW  - idiopathic pulmonary fibrosis
KW  - biomarker
KW  - recurrent implantation failure
KW  - severe acute respiratory syndrome coronavirus
KW  - miRSNP
KW  - transfer
KW  - miR-106a-5p
KW  - somatostatin analogues
KW  - neuroendocrine tumors
KW  - gene expression
KW  - uremia
KW  - HKII
KW  - miRNAs
KW  - metabolic interactions
KW  - non-Hodgkin lymphoma
KW  - PIK3R1
KW  - small RNA
KW  - miR-7
KW  - Hexokinase 2
KW  - CD34 cryptic splicing
KW  - systemic sclerosis
KW  - small RNA-seq
KW  - myogenic differentiation
KW  - proteomics
KW  - CD34 cell-clusters
KW  - palindromic small RNA
KW  - infertility
KW  - gut microbiota
KW  - ORF miRNA target
KW  - DNA complemented palindrome
KW  - rs17723799
KW  - complemented palindromic small RNA
KW  - MIR143
KW  - microRNA
KW  - cancer
KW  - muscle atrophy
N1  - Open Access
N2  - MicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models
UR  - https://mdpi.com/books/pdfview/book/2044
UR  - https://directory.doabooks.org/handle/20.500.12854/53437
ER  -